Association between phosphoglucomutase (PGM1) and group-specific component (Gc) subtypes and tuberculosis.

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Association between phosphoglucomutase (PGM1) and group-specific component (Gc) subtypes and tuberculosis.

The polymorphism of PGM1 and Gc was studied by isoelectric focusing in pulmonary tuberculosis patients and controls. For the Gc system, the phenotypic frequencies did not differ significantly, but the PGM1 system showed a significant difference in the tuberculosis patients compared to controls. The data presented here show the potential of newly developed techniques to distinguish subjects with...

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subtype determination of phosphoglucomutase (pgm) and group- specific component (gc) by isoelectric focusing among some iranian populations

a total of 781 serum and 827 red cell samples from four populations of iran (kashan, ardestan, asrara and ardabil) were sub-typed by isoelectric focusing for group-specific componet and red cell enzyme phosphoglucomutase, locus one, respectively. heterogeneity test revealed no significant differences among the populations studied regarding both pgm1 and gc systems.

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Mapping recombination hotspots in human phosphoglucomutase (PGM1).

Human phosphoglucomutase (PGM1) is a highly poly-morphic protein. Three mutations and four intragenic recombination events between the three mutation sites generate eight protein variants including the four universally common alleles, 1+, 1 -, 2+ and 2 -, and four others that are polymorphic in some Oriental populations, 3+, 3-, 7+ and 7-. The mutations 3/7, 2/1 and +/-are in exons 1A, 4 and 8,...

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association between tuberculosis and smoking

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ژورنال

عنوان ژورنال: Journal of Medical Genetics

سال: 1983

ISSN: 1468-6244

DOI: 10.1136/jmg.20.3.220